منابع مشابه
Cortical actin dynamics driven by formins and myosin V.
Cell morphogenesis requires complex and rapid reorganization of the actin cytoskeleton. The budding yeast Saccharomyces cerevisiae is an invaluable model system for studying molecular mechanisms driving actin dynamics. Actin cables in yeast are formin-generated linear actin arrays that serve as tracks for directed intracellular transport by type V myosins. Cables are constantly reorganized thro...
متن کاملCortical Actin Dynamics Facilitate Early-Stage Centrosome Separation
Proper centrosome separation is a prerequisite for positioning the bipolar spindle. Although studies demonstrate that microtubules (MTs) and their associated motors drive centrosome separation [1], the role of actin in centrosome separation remains less clear. Studies in tissue culture cells indicate that actin- and myosin-based cortical flow is primarily responsible for driving late centrosome...
متن کاملSignaling to Actin Dynamics
Address correspondence to Laura Machesky, Department of Biochemistry, University of Birmingham, Birmingham B15 2TT, UK. Tel: 44-121414-2504. Fax: 44-121-414-3982. E-mail: [email protected] or [email protected] T HE actin cytoskeleton of a eukaryotic cell is central to locomotion, phagocytosis, contractility, shape changes, cytokinesis and maintenance of polarity. The mechanisms throug...
متن کاملMeasuring Actin Dynamics
The actin cytoskeleton is a highly dynamic system responsible for maintaining cell shape and rigidity. In endothelial cells, the actin cytoskeleton undergoes a remarkable reorganization in response to shear at the cell surface. This rearrangement likely occurs through regulation of cytoskeletal dynamics. This thesis presents a viable technology for the measurement of two fundamental dynamic pro...
متن کاملModeling actin dynamics.
Actin monomers assemble into filaments that structurally support cells as well as drive membrane protrusion for cell movement. Within cells, some actin structures are very dynamic and turn over rapidly, while others are very stable. Even purified actin filament dynamics are complex, and researchers have often turned to mathematical models in order to interpret data, test hypotheses, make predic...
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ژورنال
عنوان ژورنال: BioArchitecture
سال: 2011
ISSN: 1949-0992,1949-100X
DOI: 10.4161/bioa.1.4.17314